Help


This page help the user to understand the IL17eScan and how to use it effectively. Here user can get the details of all the procedures present in the different modules in a step-wise manner. User can directly go to the particular section by clicking the respective menu present in the main table.


PEPPREDPEPSCANMETAGSCANEPISCANSIMSEARCH

PepScan:Peptide Prediction



This page is designed to facilitate user to predict IL-17 inducing property of peptides. User is allowed to query by pasting one or more peptide sequences in Fasta format or upload a Fasta file as shown below. The threshold value can be selected from -1.0 to 1.0 with 0.1 step size, to set the stringency of predictions. On increasing the threshold towards 1, the specificity will increase and the number of false positives will decrease.
Click Submit button to view the result page.

Picpep-1


In the result page of Peptide prediction, query peptides are listed with scores of prediction and the predicton result (IL-17 inducing or negative. The option to download the results is also provided. User can click on a peptide for its virtual screening, a process which predict the IL-17 inducing property of all of its variants.

Picpep-2

PepScan:Protein Scan



This page is designed to facilitate user to scan the presence of proinflamatory sequences in a protein. Query by pasting one or more protein sequences in Fasta format or upload a Fasta file as shown below. User can change the window length of the peptide sequences, between 5 and 30, used for prediction. The Threshold value can be altered from -1.0 to 1.0 with 0.1 step size, to set the stringency of predictions. On increasing the threshold towards 1, the specificity will increase and the number of false positives will decrease.
Click Submit button to view the result page.

Picprot-1


In the result page of Protein scan, query peptides are marked with predicted epitopes(in blue colour but start with red color). User can click to view detailed result. Results can be downloaded also.

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MetaGScan:Metagenome Scan



This tool enables user to identify IL-17 inducing antigenic regions in metagenomic reads in the form of protein sequences. In view to the large size of metagenomic reads, AAC-based prediction models were incorporated in this module. Here user can select desired length of peptide for prediction.

Picprot-1


In the result page of Protein scan, query peptides are marked with predicted epitopes(in blue colour but start with red color). User can click to view detailed result. Results can be downloaded also.

Picprot-2

EpiScan:Epitope Scanning



This page is designed to facilitate user to map experimentally validated IL-17 inducing epitopes, into protein/peptide sequences of interest. Query by pasting one or more sequences in Fasta format or upload a Fasta file as shown below. Click Submit button to view the result page.

Picepi-1

SimSearch:Similarity Search



This page is designed to facilitate user to do Similarity Search of sequence of interest, against experimantaly validated proinflamatory Epitopes in IEDB(Immune Epitope Databse and analysis Sourse) database. User is allowed to query by pasting one or more peptide sequences in Fasta format or upload a Fasta file as shown below. Click Submit button to view the result page.

Picsimi-1